Ampulla of Vater carcinoma: Molecular landscape and clinical implications

Undifferentiated carcinoma of the ampulla of Vater

Undifferentiated carcinoma of the ampulla of Vater is a rare disease with unclear and clinical characteristics and prognosis. Here, we report the case of a 61-year-old man with undifferentiated carcinoma of the ampulla of Vater. He presented to our hospital with an increase in hepatobiliary system enzymes that was detected during a health check-up. Imaging and endoscopy demonstrated a tumor wit...

Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer

Carcinoma of the papilla of Vater is a relatively rare tumor and its coexistence with other primary sporadic cancers is very exceptional. Here we report the case of a 76-year-old man who presented with painless obstructive jaundice, pathologically elevated liver function tests and increased serum levels of carbohydrate antigen 19-9 and carcinoembryonic antigen. Endoscopic retrograde cholangiogr...

Dermatomyositis/polymyositis and carcinoma of the ampulla of Vater.

Carcinoma of Ampulla of Vater: Carcinogenesis and Immunophenotypic Evaluation

The ampulla of Vater represents the epithelial junction of the main pancreatic duct and the distal bile duct, surrounded by the pancreatic head and duodenum parenchyma. Ampullary carcinoma can arise either from the intestinal epithelium or the epithelium covering the pancreatobiliary ducts. Many tumors develop from pre-existing adenomas, others evolve from precursor intraepithelial neoplasia su...

Large cell neuroendocrine carcinoma of the ampulla of vater.

We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery. Microscopically, the tumor was extensively necrotic. It was composed of islands and trabeculae irregularly infiltrating the muscular wall of the duodenum. Neoplastic ce...